Transendothelial migration drives dissociation of plateletmonocyte complexes.

Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality

Human monocytes adhere to activated platelets, resulting in the formation of plateletmonocyte complexes (PMC). Complex formation depends on the interaction between platelet-displayed P-selectin and the specific ligand for Pselectin on leukocytes, P-selectin glycoprotein ligand-1 (PSGL-1). We have recently shown that monocytes within a PMC have increased adhesive capacity to the activated endoth...

Signaling in leukocyte transendothelial migration.

Under a variety of (patho) physiological conditions, leukocytes will leave the bloodstream by crossing the endothelial monolayer that lines the vessels and migrate into the underlying tissues. It is now clear that the process of extravasation involves a range of adhesion molecules on both leukocytes and endothelial cells, as well as extensive intracellular signaling that drives adhesion and che...

Underexpression of RhoH in Hairy Cell Leukemia.

The cause of hairy cell leukemia (HCL) is unknown. Current treatments seem effective only for a limited period of time. In addition, a significant proportion of patients remain refractive to all treatment options. These considerations indicate the need to develop alternative therapeutic strategies for HCL. Here, we report that HCL is characterized by underexpression of RhoH. In vitro reconstitu...

MRP8 AND MRP14 CONTROL MICROTUBULE REORGANIZATION DURING TRANSENDOTHELIAL MIGRATION OF PHAGOCYTES. running title: MRP8/MRP14 complexes and migration of phagocytes

Impairment of transendothelial leukocyte migration by iron complexes.

Although iron sucrose and iron gluconate are generally well tolerated in patients who are treated for renal anemia, recent clinical studies and cell culture experiments suggested significant toxicity and long-term side effects arising from the use of these iron complexes. Because of the possible role of iron in infection or cardiovascular disease, it was theorized that parenteral iron compounds...